Endothelin-1, big endothelin-1, and nitric oxide in patients with chronic renal disease and hypertension
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چکیده
منابع مشابه
Hemodynamic effects of endothelin-1 and big endothelin-1 in chronic hemodialysis patients.
Increased plasma concentrations of endothelin-1 (ET-1) and big endothelin-1 (big ET-1) have been reported in patients with end-stage renal failure (ESRD). In the present study, which included hemodialysis (HD) patients with (n = 21) and without (n = 32) ischemic heart disease, the putative association between plasma levels of ET-1 and big ET-1 and ischemic heart disease and the influence of the...
متن کاملNitric oxide-endothelin-1 interaction in humans.
Healthy men received NG-monomethyl-L-arginine (L-NMMA) intravenously to study cardiovascular and metabolic effects of nitric oxide synthase blockade and whether this alters the response to endothelin-1 (ET-1) infusion. Controls only received ET-1. L-NMMA effects were that heart rate (17%) cardiac output (17%), and splanchnic and renal blood flow (both 33%) fell promptly (all P < 0.01). Mean art...
متن کاملEndothelin A receptor blockade alleviates hypertension and renal lesions associated with chronic nitric oxide synthase inhibition.
Unopposed actions of vasoconstrictors, such as angiotensin, play an important role in the effects of chronic nitric oxide synthase (NOS) inhibition. In this study, it is hypothesized that endothelin (ET), another important vasoconstrictor, may also play a role in the development of hypertension and renal lesions during chronic NOS inhibition. The ET(A) receptor was blocked with A-127722 during ...
متن کاملThe role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in diabetic patients.
The pathogenesis of renal hypertension has not yet been fully clarified. As the potential role of endothelin-1 (ET-1) and nitric oxide (NO) has been postulated, their concentrations were determined in plasma and urine of diabetic patients. The study included 30 diabetic patients (both IDDM and NIDDM) with initial or advanced diabetic nephropathy (decreased endogenous creatinine clearance, prote...
متن کاملModulation of circulating endothelin-1 and big endothelin by nitric oxide inhalation following left ventricular assist device implantation.
BACKGROUND Inhaled nitric oxide (iNO) is an established therapy in the treatment of pulmonary hypertension and right ventricular dysfunction following left ventricular assist device implantation. Since it is known that endothelin-1 contributes to pulmonary hypertension, and nitric oxide modulates endothelin-1 synthesis in vitro, we investigated the effects of iNO on circulating endothelin-1 and...
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ژورنال
عنوان ژورنال: Journal of Clinical Laboratory Analysis
سال: 2009
ISSN: 0887-8013,1098-2825
DOI: 10.1002/jcla.20324